Crystal structure of a small heat-shock protein from Xylella fastidiosa reveals a distinct high-order structure
Fonseca, Emanuella Maria Barreto; Scorsato, Valeria; dos Santos, Marcelo Leite; Tomazini, Atilio; Tada, Susely Ferraz Siqueira; dos Santos, Clelton Aparecido; de Toledo, Marcelo Augusto Szymanski; de Souza, Anete Pereira; Polikarpov, Igor; Aparicio, Ricardo
Citrus variegated chlorosis is a disease that attacks economically important citrus plantations and is caused by the plant-pathogenic bacterium Xylella fastidiosa. In this work, the structure of a small heat-shock protein from X. fastidiosa (XfsHSP17.9) is reported. The high-order structures of small heatshock proteins from other organisms are arranged in the forms of double-disc, hollow-sphere or spherical assemblies. Unexpectedly, the structure reported here reveals a high-order architecture forming a nearly square cavity.