The ecological model of niche MaxEnt has been used to know the potential distribution of Xylella fastidiosa subsp. multiplex and the associated vector Philaenus spumarius in the south of the Iberian Peninsula. The correlation of the probability of the presence of the bacterium with respect to the vector insect is 94 %, confirming the existence of a pathogen-vector system. The internal validation of the model shows AUC coefficients above 90 %. The external validations of the omission and commission errors have been made by correlating the probability values obtained by a multivariate mathematical model and 914 independent points obtained from the last infection, which have given a correlation of the model prediction above 80 %.